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American scientists Victor Ambros of the UMass Chan Medical School and Gary Ruvkun of Harvard Medical School were awarded the Nobel Prize in Medicine on Monday for discovering microRNA, as well as their role in “post-transcriptional gene regulation.”

We have no idea what that means. But we do know that earlier this year, Danish pharma giant Novo Nordisk (of Ozempic fame) acquired a German firm whose lead drug candidate blocks abnormal levels of a microRNA molecule. The hope is that it will counter heart ailments by strengthening the organ’s walls: a noble endeavor indeed. 

Energy

Chevron and BP Hone Core Focus Amid Promising Oil Future

Photo of a BP gas station
Photo by Jetcityimage via iStock

Monday saw oil giants Chevron and BP make moves to refine their business, drilling down on core segments that crude demand assures will be gushing with wealth.

Chevron announced it will bank $6.5 billion from the sale of high-cost oil sands assets so it can focus on the more profitable US Permian Basin. Meanwhile, BP is treating earlier goals like a misbegotten New Year’s resolution: It’s dumping its target to cut oil and gas output and chasing higher returns instead.

In the Mood for Crude

Global instability has been a friend to oil prices of late: On Monday, Brent rose to $80 a barrel, its highest point since August, while US benchmark West Texas Intermediate crude climbed more than 3% to about $77 a barrel. “The angst is building,” Rebecca Babin, a senior energy trader at CIBC Private Wealth Group, told Bloomberg.

The first half of 2024, meanwhile, was defined by a wave of megamergers among US oil and gas producers — M&A activity driven by the fact that firms are flush with cash in the wake of Russia’s invasion of Ukraine and crude demand is poised to remain strong for years to come. But as Monday’s news showed, it’s not just strategic mergers that will drive Big Oil’s profit-hunting:

  • In Chevron’s case, strategic divestment makes sense: By selling its 20% stake in the Athabasca Oil Sands and a 70% interest in the Duvernay shale to Canadian Natural Resources, it will net $6.5 billion in cash. That’s a huge step forward in its plan to offload $10 billion to $15 billion in assets by 2028 so it can focus on the Permian Basin and Kazakhstan (Chevron is also finalizing a $53 billion megamerger to acquire Hess).
  • UK oil giant BP, which has been slammed for missing profit forecasts, is abandoning a plan to cut oil and gas output 25% by 2030 — a goal that was already scaled back from 40% last year — sources told Reuters. The news agency reported that BP is seeking out new oil and gas investments in the Middle East and the Gulf of Mexico to maximize its profitability over previous environmental pledges.

Dollars in Quicksand: Canada’s energy industry saw its own surge in acquisitions late last year, which Chevron’s deal now contributes to. For the US giant, getting out of Canada is a question of margins: Operating costs in oil sands are much higher than other methods of oil extraction, with the current breakeven Brent price for a barrel of oil sands at $57, compared to North American shale at $45.

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Technology

Obesity Drugmaker Rivus Wants in on the Healthcare IPO Boom

Two is a coincidence, three is a trend. Here come all the trend-followers.

September marked one of the biggest months in years for healthcare IPOs, and Bloomberg reported Monday that obesity drugmaker Rivus is working with banks to complete a US public listing that could happen before the end of the year.

Health Makes Wealth

Rivus has good reason to be optimistic about its pipeline. Last week, the biotech firm published positive results for the phase 2 trial of its lead asset, a once-daily oral drug called HU6 that’s intended to help patients with obesity. While current leading anti-obesity drugs largely promote weight loss by sending signals to patients’ brains that affect their appetite, thus reducing caloric intake, HU6 is designed to boost the breakdown of fat in the body by preventing it from accumulating in the first place. The latest trial results, crucially, showed the drug helped patients lose weight while preserving muscle mass — an especially critical asset for patients suffering from obesity-related heart failure. 

The company also has plenty of reasons to be optimistic about a warm market welcome:

  • Last month saw the successful debut of at least four biotech firms: Zenas BioPharma, MBX Biosciences, Bicara Therapeutics, and BioAge Labs (which is also developing weight-loss drugs). Shares of each firm are still trading above their initial listing price.
  • So far this year, biopharma IPOs on US exchanges have raised $3.2 billion, according to data compiled by Bloomberg, more than was raised by the industry in the first nine months of 2023 and 2022.

Join the Club: Rivus may aim to raise more than $250 million, one source told Bloomberg. And it’s not alone in its rush to the market. Also eyeing an imminent IPO, according to a recent Reuters report: Upstream Bio, which is developing respiratory disorder treatments; Ceribell, which makes monitors to detect neurological conditions; and CAMP4 Therapeutics, which is developing therapies for genetic diseases. “(Biotechs) may want to capture the current market momentum rather than waiting for elections or economic indicators,” Zara Muradali, national industry managing principal of Grant Thornton’s life sciences industry practice, told Reuters.

Technology

The United Nations Wants to Stamp Out Cybercrime

Cybercrime is a lot like the weather lately: extreme and getting worse.

On Monday, the United Nations published a new report about an alarming spike in cybercrime last year, specifically from a growing number of syndicates in Southeast Asia. The report comes just as the international governing group pushes forward on a controversial new treaty to combat the cybercrime wave.

Trick-or-Treaty

New tech is enabling new types of crime. The rise of generative artificial intelligence, deepfake technology, and money laundering-enabling cryptocurrency systems has created “a powerful force multiplier for criminal activities,” the report says, with cybercrime syndicates in Southeast Asia costing victims as much as $37 billion in 2023.

It comes as no surprise then that the UN has been moving to create a new treaty that would establish global standards for combating cybercrime. Final draft text for the treaty was adopted late last month, with an official vote from the UN General Assembly due sometime before the end of the year. Despite criticism from both human rights groups and major tech firms, the treaty has widespread support from member nations — though one key player is beginning to express disapproval:

  • Critics — including tech industry groups as well as human rights and civil liberties organizations such as Human Rights Watch and the Electronic Frontier Foundation — have said the treaty gives individual nations far too much power for digital surveillance of citizens, with thin language protecting their civil rights.
  • The Biden White House is increasingly unsure if it will back the treaty over the same concerns, Politico reported. If the US votes no or abstains, the drafting process would effectively start from scratch — which some say could result in a treaty with even fewer protections for civil liberties.

In the Lab: Still, as Monday’s report makes clear, cybercrime is increasing, and only growing more sophisticated. “[Southeast Asia] is ground zero for the scamming industry in terms of innovation, in terms of the way that things develop,” a UN official told Voice of America. In other words: You ain’t seen nothing yet. 

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Extra Upside

  • Hoping for a Correction: Shares in backup power generator-maker Generac surged Monday, with Hurricane Milton expected to hit Florida later this week. 
  • IPOh!: The US IPO market is poised to welcome nine deals this week, led by kindergarten operator KinderCare, that will raise a combined $1.4 billion.
  • Deadline Deal: After the shock retirement of NBA insider Adrian Wojnarowski, ESPN is poaching his protégé-turned-rival Shams Charania from the New York Times-owned The Athletic.

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